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Development
of surface plasmon resonance (SPR) spectroscopy as state-of-the-art
technology for bioanalytical applications.
1. Miniaturization of optical SPR biosensors to develop
scanning probe SPR microscopy. The research group is
developing methodology to enable the miniaturization
of SPR biosensors for their integration in atomic force
microscopy (AFM). This will allow a great improvement of
spatial resolution of SPR sensors. The application of the
miniature SPR biosensors will open new research endeavours
in cell and disease research.
2. Improvement of conventional configuration SPR biosensors
for applied bioanalysis. The research group is developing
novel SPR biosensors to overcome current SPR limitations,
to improve detection of low molecular weight molecules and
of biomolecules in real biological samples.
SPR biosensors developed in the group are applied towards
the detection of pharmaceutical compounds and cancer
markers, and to monitor molecular transport through cellular
membranes. Novel monolayer chemistry is also investigated
for biosensor design.
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